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がんリンパ節転移診断システム(OSNA法) 遺伝子増幅検出装置 RDシリーズ RD-200、RD-100i

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OSNA™ 乳がん

2014年

Bettington M, et al. : Is the one-step nucleic acid amplification assay better for intra-operative assessment of breast sentinel nodes? : ANZ J Surg. 2014
Osako T, et al. : Incidence and predictor of invasive disease and nodal metastasis in preoperatively diagnosed ductal carcinoma in situ. : Cancer Sci. 2014
Tiernan JP , et al. : Systematic review and meta-analysis of cytokeratin 19-based one-step nucleic acid amplification versus histopathology for sentinel lymph node assessment in breast cancer. : Br J Surg. 2014
Banerjee SM, et al. : Detailed evaluation of one step nucleic acid (OSNA®) molecular assay for intra-operative diagnosis of sentinel lymph node metastasis and prediction of non-sentinel nodal involvement: Experience from a London Teaching Hospital. : Breast. 2014
Hoon DS, et al. : Molecular analysis of sentinel lymph nodes and search for molecular signatures of the metastatic potential of breast cancer. : Q J Nucl Med Mol Imaging. 2014
Pathmanathan N, et al. : Intraoperative sentinel lymph node assessment in breast cancer: a comparison of rapid diagnostic method based on CK19 mRNA expression and imprint cytology. : ANZ J Surg. 2014
Deambrogio C, et al. : A new clinical cut-off of cytokeratin 19 mRNA copy number in sentinel lymph node better identifies patients eligible for axillary lymph node dissection in breast cancer. : J Clin Pathol. 2014
Teramoto A, et al. : One-step nucleic acid amplification assay for intraoperative prediction of non-sentinel lymph node metastasis in breast cancer patients with sentinel lymph node metastasis. : Breast. 2014
Ruano MA, et al. : An improved axillary staging system using the OSNA® assay does not modify the therapeutic management of breast cancer patients : Sci Rep. 2014
Mokhtar M, et al. : Triple assessment of sentinel lymph node metastasis in early breast cancer using preoperative CTLG, intraoperative fluorescence navigation and OSNA®. : Breast Cancer. 2014
Rubio IT, et al. : Nomogram including the total tumoral load in the sentinel nodes assessed by one-step nucleic acid amplification as a new factor for predicting nonsentinel lymph node metastasis in breast cancer patients. : Breast Cancer Res Treat. 2014
Jara-Lazaro AR, et al. : Assessment of suitability of the one step nucleic acid amplification (OSNA®) assay as an intraoperative procedure for detection of metastasis in sentinel lymph nodes of breast cancer. : J Clin Pathol. 2014
Terada M, et al. : Comparative Study of the One-step Nucleic Acid Amplification Assay and Conventional Histological Examination for the Detection of Breast Cancer Sentinel Lymph Node Metastases. : Tokai J Exp Clin Med. 2014
Piñero-Madrona A, et al. : Tumoral load quantification of positive sentinel lymph nodes in breast cancer to predict more than two involved nodes. : Breast. 2014
Raia-Barjat T, et al. : OSNA® (one-step nucleic acid amplification) sentinel lymph node intraoperative molecular analysis in breast cancer: a cost-benefit analysis. : Med Oncol. 2014
Babar M, et al. : One Step Nucleic Acid Amplification (OSNA®) positive micrometastases and additional histopathological NSLN metastases: Results from a single institution over 53 months : Surgeon. 2014

2013年

Osako T,et al. : Sentinel node tumour burden quantified based on cytokeratin 19 mRNA copy number predicts non-sentinel node metastases in breast cancer: Molecular whole-node analysis of all removed nodes. : Eur J Cancer. 2013
Osako T, et al. : Detection of occult invasion in cases of ductal carcinoma in situ of the breast along with sentinel node metastasis. : Cancer Sci. 2013
Remoundos DD, et al. : The use of one step nucleic-acid amplification (OSNA®) in clinical practice: A single-centre study. : Breast. 2013
Chen JJ, et al. : Comparison of molecular analysis and touch imprint cytology for the intraoperative evaluation of sentinel lymph nodes in primary breast cancer: Results of the China Breast Cancer Clinical Study Group (CBCSG) 001c trial. : Eur J Surg Oncol. 2013
Li D, et al. : Utility of one-step nucleic acid amplification (OSNA®) assay in detecting breast cancer metastases of sentinel lymph nodes in a Chinese population. : Breast Cancer. 2013
Buglioni S, et al. : Quantitative molecular analysis of sentinel lymph node may be predictive of axillary node status in breast cancer classified by molecular subtypes. : PLoS One. 2013
Peg V, et al. : Intraoperative molecular analysis of total tumor load in sentinel lymph node: a new predictor of axillary status in early breast cancer patients. : Breast Cancer Res Treat. 2013
Espinosa-Bravo M, et al. : Prediction of non-sentinel lymph node metastasis in early breast cancer by assessing total tumoral load in the sentinel lymph node by molecular assay. : Eur J Surg Oncol. 2013
Klingler S, et al. : Using one-step nucleic acid amplification (OSNA®) for intraoperative detection of lymph node metastasis in breast cancer patients avoids second surgery and accelerates initiation of adjuvant therapy. : Ann Oncol. 2013
Navarro-Cecilia J, et al. : Intraoperative sentinel node biopsy by one-step nucleic acid amplification (OSNA®) avoids axillary lymphadenectomy in women with breast cancer treated with neoadjuvant chemotherapy. : Eur J Surg Oncol. 2013
Pegolo E, et al. : One-step nucleic acid amplification (OSNA®) for intraoperative evaluation of sentinel lymph node status in breast cancer: a comparative study between CK19 protein expression and CK19 mRNA level in primary tumors and lymph node metastasis. : Virchows Arch. 2013
Rebollo-Aguirre AC, et al. : Sentinel lymph node biopsy after neoadjuvant chemotherapy in patients with operable breast cancer and positive axillary nodes at initial diagnosis (Article in Spanish) : Rev Esp Med Nucl Imagen Mol. 2013
Smolarz B, et al. : Comparison of one-step nucleic acid amplification (OSNA®) method and routine histological investigation for intraoperative detection of lymph node metastasis in Polish women with breast cancer. : Pol J Pathol. 2013
Wang YS, et al. : Prospective multi-center study of one-step nucleic acid amplification assay for the detection of sentinel lymph nodes metastases in breast cancer patients (Article in Chinese) : Zhonghua Yi Xue Za Zhi. 2013
Heilmann T, et al. : Intra-operative use of one-step nucleic acid amplification (OSNA®) for detection of the tumor load of sentinel lymph nodes in breast cancer patients. : J Cancer Res Clin Oncol. 2013
Osako T, et al. : Molecular detection of lymph node metastasis in breast cancer patients treated with preoperative systemic chemotherapy: a prospective multicentre trial using the one-step nucleic acid amplification assay : Br J Cancer. 2013
Jimbo K, et al. : Sentinel and nonsentinel lymph node assessment using a combination of one-step nucleic acid amplification and conventional histological examination. : Breast. 2013
Santaballa A, et al. : Advantages of one step nucleic acid amplification (OSNA®) whole node assay in sentinel lymph node (SLN) analysis in breast cancer. : Springerplus. 2013
Babar M, et al. : A differential intra-operative molecular biological test for the detection of sentinel lymph node metastases in breast carcinoma. An extended experience from the first UK centre routinely offering the service in clinical practice. : Eur J Surg Oncol. 2013
Chaudhry A, et al. : The real-time intra-operative evaluation of sentinel lymph nodes in breast cancer patients using One Step Nucleic Acid Amplification (OSNA®) and implications for clinical decision-making. : Eur J Surg Oncol. 2013

2012年

Castellano I, et al. : Reliability of Whole Sentinel Lymph Node Analysis by One-Step Nucleic Acid Amplification for Intraoperative Diagnosis of Breast Cancer Metastases. : Ann Surg. 2012
Cserni G, et al. : Intraoperative analysis of sentinel lymph nodes in breast cancer by one-step nucleic acid amplification. : J Clin Pathol. 2012
Tamaki Y, et al. : Routine clinical use of the one-step nucleic acid amplification assay for detection of sentinel lymph node metastases in breast cancer patients: Results of a multicenter study in Japan : Cancer. 2012
Osako T, et al. : Incidence and possible pathogenesis of sentinel node micrometastases in ductal carcinoma in situ of the breast detected using molecular whole lymph node assay. : Br J Cancer. 2012
Laia BV, et al. : Comparison of Molecular Analysis and Histopathology for Axillary Lymph Node Staging in Primary Breast Cancer: Results of the B-CLOSER-I Study. : Diagn Mol Pathol. 2012
Vilardell F, et al. : Importance of assessing CK19 immunostaining in core biopsies in patients subjected to sentinel node study by OSNA®. : Virchows Arch. 2012
Tamaki Y, et al. : One-step nucleic acid amplification assay (OSNA®) for sentinel lymph node biopsy. : Breast Cancer. 2012
Wang YS, et al. : A comparative study of one-step nucleic acid amplification assay, frozen section and touch imprint cytology for intraoperative assessment of breast sentinel lymph node in Chinese patients : Cancer Science. 2012
Ohi Y, et al. : Whole sentinel lymph node analysis by a molecular assay predicts axillary node status in breast cancer. : Br J Cancer. 2012

2011年

Feldman S, et al. : A novel automated assay for the rapid identification of metastatic breast carcinoma in sentinel lymph nodes. : Cancer. 2011
Khaddage A, et al. : Implementation of Molecular Intra-operative Assessment of Sentinel Lymph Node in Breast Cancer. : Anticancer Res. 2011
Osako T, et al. : Intraoperative molecular assay for sentinel lymph node metastases in early stage breast cancer. : Cancer. 2011
Laia BV, et al. : Molecular Diagnosis of Sentinel Lymph Nodes for Breast Cancer: One Step Ahead for Standardization : Diagn Mol Pathol. 2011
Laia BV, et al. : Diagnosis of the sentinel lymph node in breast cancer: a reproducible molecular method: a multicentric Spanish study : Histopathology. 2011
Guillén-Paredes MP, et al. : One-step nucleic acid amplification (OSNA®) assay for sentinel lymph node metastases as an alternative to conventional postoperative histology in breast cancer: A cost-benefit analysis. : Cir Esp. 2011
Le Frère-Belda MA, et al. : Diagnostic performance of one-step nucleic acid amplification for intraoperative sentinel node metastasis detection in breast cancer patients : Int J Cancer. 2011
Osako T, et al. : Accurate staging of axillary lymph nodes from breast cancer patients using a novel molecular method : British Journal of Cancer. 2011
Godey F, et al. : Sentinel lymph node analysis in breast cancer: contribution of one-step nucleic acid amplification (OSNA®) : Breast Cancer Res Treat. 2011
Sagara Y, et al. : Clinical application of the one-step nucleic acid amplification method to detect sentinel lymph node metastasis in breast cancer. : Breast Cancer. 2011

2010年

Snook KL, et al. : Multicentre evaluation of intraoperative molecular analysis of sentinel lymph nodes in breast carcinoma : British Journal of Surgery. 2010
Yoon-La Choi, et al. : One-step Nucleic Acid Amplification (OSNA®): Intraoperative Rapid Molecular Diagnostic Method for the Detection of Sentinel Lymph Node Metastases in Breast Cancer Patients in Korean Cohort : Journal of Breast Cancer. 2010

2009年

Schem C, et al. : One-step nucleic acid amplification-a molecular method for the detection of lymph node metastases in breast cancer patients; results of the German study group. : Virchows Arch. 2009
Tamaki Y, et al. : Molecular detection of lymph node metastases in breast cancer patients: results of a multicenter trial using the one-step nucleic acid amplification assay. : Clin Cancer Res. 2009

2008年

Visser M, et al. : Intra-operative rapid diagnostic method based on CK19 mRNA expression for the detection of lymph node metastases in breast cancer. : Int J Cancer. 2008

2007年

Tsujimoto M, et al. : One-step nucleic acid amplification for intraoperative detection of lymph node metastasis in breast cancer patients. Clinical Cancer Research. 2007

OSNA™ 大腸がん

2014年

Croner RS, et al. : Molecular staging of lymph node-negative colon carcinomas by one-step nucleic acid amplification (OSNA®) results in upstaging of a quarter of patients in a prospective, European, multicentre study. : Br J Cancer. 2014
Coget J, et al. : The intraoperative study of the sentinel lymph node was made possible through molecular analysis: A new concept and new applications for colon cancer?(Article in French) : Bull Cancer. 2014
Vogelaar FJ, et al. : The Diagnostic Value of One-Step Nucleic acid Amplification (OSNA®) for Sentinel Lymph Nodes in Colon Cancer Patients. : Ann Surg Oncol. 2014

2013年

Yamamoto N, et al. : An Optimal mRNA Marker for OSNA® (One-step Nucleic Acid Amplification) Based Lymph Node Metastasis Detection in Colorectal Cancer Patients. : Jpn J Clin Oncol. 2013

2012年

Güller U, et al. : Molecular investigation of lymph nodes in colon cancer patients using one-step nucleic acid amplification (OSNA®): A New Road to Better Staging? : Cancer. 2012

2011年

Yamamoto H, et al. : OSNA®-Based Novel Molecular Testing for Lymph Node Metastases in Colorectal Cancer Patients: Results from a Multicenter Clinical Performance Study in Japan. : Annals of Surgical Oncology. 2011

2010年

Croner RS, et al. : One Step Nucleic Acid Amplification (OSNA®) - a new method for lymph node staging in colorectal carcinomas. : J Transl Med. 2010

OSNA™胃がん

2013年

Kumagai K, et al. : Multicenter study evaluating the clinical performance of the OSNA® assay for the molecular detection of lymph node metastases in gastric cancer patients. : Gastric Cancer. 2013

2011年

Yaguchi Y, et al. : One-Step Nucleic Acid Amplification (OSNA®) for the Application of Sentinel Node Concept in Gastric Cancer : Annals of Surgical Oncology. 2011

OSNA™ 非小細胞肺がん

2016年

Nakagawa K, et al. : The novel one-step nucleic acid amplification (OSNA) assay for the diagnosis of lymph node metastasis in patients with non-small cell lung cancer (NSCLC): Results of a multicenter prospective study. : Lung Cancer. 2016
Tamaki Y, et al. :One-step nucleic acid amplification (OSNA): where do we go with it? : Int J Clin Oncol. 2016

2015年

Oezkan F, et al. : OSNA: A Fast Molecular Test Based on CK19 mRNA Concentration for Assessment of EBUS-TBNA Samples in Lung Cancer Patients. : Clin Lung Cancer. 2015

2014年

Masai K, et al. : Cytokeratin 19 expression in primary thoracic tumors and lymph node metastases : Lung Cancer. 2014

2013年

Hayama M, et al. : One-step Nucleic Acid Amplification for Detection of Lymph Node Metastasis in Lung Cancer. : Ann Thorac Cardiovasc Surg. 2013

2012年

Inoue M, et al. : An accurate and rapid detection of lymph node metastasis in non-small cell lung cancer patients based on one-step nucleic acid amplification assay : Lung Cancer. 2012